By Ludger Rensing,Volkhard Rippe
Das für ein breites Publikum geschriebene Werk zeigt die kausalen Verbindungen zwischen den messbaren Alterserscheinungen und den zugrundeliegenden Veränderungen in Genen, Zellen und in deren Kommunikationssystemen auf. Molekularbiologische Ansätze gewinnen in Medizin und Pharmakologie immer mehr an Bedeutung (Molekulare Medizin, targeted therapies, genombasierte personalisierte Medizin), und Kenntnisse über kausale Mechanismen der Alterung werden die Vorsorge und Therapie zahlreicher Alterskrankheiten deutlich verbessern können. Die Autoren erläutern diese Zusammenhänge an elf menschlichen Funktionssystemen: Haut, Knochenskelett, Muskulatur, Kreislauf und Lunge, Immunsystem, Verdauungssystem, Ausscheidungssystem, Sexualität und Fortpflanzung, Hormonsystem, zentrales Nervensystem und Sinnesorgane.
Jedes Kapitel beginnt mit einer kurzen Übersicht über die normalen Funktionen des Systems; dann werden die altersabhängigen Veränderungen und Erkrankungen mit den zugrundeliegenden molekularen Mechanismen dargestellt. Abschließend gehen die Autoren auf einige medizinische Aspekte von Alterserkrankungen und wichtige therapeutische Ansätze ein. Am Anfang des Buches steht ein einführendes Kapitel über die grundlegenden (evolutions)biologischen Fragen zu Alterungsvorgängen, gefolgt von einer Übersicht über den gegenwärtigen Stand der Altersforschung und die wichtigsten Alterstheorien, darunter die Theorie der Schadensakkumulation und die Theorie der Verkürzung der Chromosomenenden (Telomere). Im letzten Kapitel des Werkes geht es schließlich um die Frage, wodurch die Korrelation zwischen adjust und dem Auftreten der meisten Krebstypen zustande kommt und welche äußeren und inneren Faktoren dabei mitwirken.
By Ann M. Dvorak
By Patria de Lancer Julnes
Expectations for functionality administration structures keep growing within the public zone. but few directors understand how to successfully enforce and maintain those platforms. Performance-Based administration structures: potent Implementation and Maintenance helps functional efforts to construct and continue functionality administration platforms in public agencies, explaining hindrances to dimension efforts and delivering tips on find out how to triumph over them.
The publication starts off by means of exploring functionality size as a key component to performance-based administration structures. It discusses its legacy and its boundaries and gives competing reasons of the standards that constrain its potent use. subsequent, it specializes in construction concept in aid of perform via a combined equipment strategy. It examines examine reconciling the conflicting reasons for the shortcoming of right use of functionality dimension info. Then it deals new insights for constructing a context-sensitive version of functionality dimension which can bring about potent practices.
The 3rd half develops those insights right into a pragmatic version of performance-based administration. It presents a pragmatic clarification of the contributions of functionality dimension and offers suggestion derived from present perform. the writer concludes by way of highlighting the reason, equipment, and findings of 2 stories that served because the origin for this e-book. She additionally offers ultimate feedback of the way to maneuver perform and conception forward.
This quantity explains why functionality dimension isn't really extra familiar within the public region, and explores how implementation of functionality size will be greater with insights won from extant literature on public coverage, organizational politics and tradition, and information usage. Mastery of this fabric will permit practitioners to appreciate easy methods to successfully enforce regulations that may certainly effect their agencies and their staff.
By Gerald Litwack
* First released in 1943, supplements and Hormones is AP's longest working serial
* each one quantity includes innovative stories by way of prime contributors
By Igor B. Buchwalow,Werner Böcker
This concise but accomplished advisor to the tools and protocols of immunohistochemistry covers demonstrated recommendations and present advancements within the box comparable to using epitope tags, a number of immunolabeling and diagnostic immunohistochemistry.
By Kwang W. Jeon
International evaluate of mobile & Molecular Biology provides present advances and complete experiences in mobile biology--both plant and animal. Articles deal with constitution and regulate of gene expression, nucleocytoplasmic interactions, regulate of telephone improvement and differentiation, and telephone transformation and growth.
* Authored by means of a few of the most appropriate scientists within the box * presents updated details and instructions for destiny learn * useful reference fabric for complicated undergraduates, graduate scholars scientists
By Hellmut G. Augustin
Endothelial mobile biology has built right into a vivid self-discipline and has develop into a severe device to review a number of sickness techniques at the mobile and molecular point. it truly is now widely known that dysfunctions of standard endothelial cellphone homeostasis are excited by one of the most very important human illnesses, together with ischemic center ailments, high blood pressure, atherosclerosis, tumors, diabetes, arthritis, and irritation. extra, the expanding significance and popularity of the sector of vascular biology mostly calls for in vitro and in vivo thoughts on the way to tackle the advanced questions.
Methods in Endothelial mobile Biology is a finished sensible "how-to"-guide summarizing the main correct validated suggestions in addition to a couple of new rising innovations. Easy-to-follow trustworthy protocols supply an invaluable lab bench source for the skilled researcher and newcomer to the sector.
By Hrayr P. Attarian
By Pramod C. Rath,Ramesh Sharma,S. Prasad
This publication provides a suite of articles on quite a few points of present examine on getting older. those comprise version structures, mobile, biochemical and molecular features of experimental getting older examine, in addition to chosen intervention stories on age-related diseases.
Aging is a world problem to human society. young children are continuously in a rush to turn into adults, whereas adults produce offspring and upload to the gene pool. in spite of the fact that, after maturity or the attainment of reproductive adulthood, all physiological parameters of the residing organism begin to suffer the getting older procedure. outdated age units in slowly yet without doubt, and customarily keeps for a chronic interval. If vigour and energy are the most merits of maturity, previous age bargains the rewards of expertise and maturity.
Biologists ask questions corresponding to: Why can we age? How can we grow old? Is it attainable to decelerate, delay or perhaps hinder getting older? In flip, health workers ask: What are the illnesses linked to previous age? Are there medications that may support affected aged sufferers? actually either teams are asking themselves how will we upload extra wellbeing and fitness to outdated age.
Healthy getting older is the dream of each person. yet to accomplish this, it really is primary that we first comprehend the mobile, biochemical and molecular foundation of the getting older technique in mammalian cells, tissues and intact dwelling organisms, that may function experimental version platforms in Biomedical Gerontology. as soon as the biology of getting older is known on the genetic and molecular degrees, interventional techniques to getting older and its linked illnesses could be more straightforward to devise and enforce on the preclinical level.
By Robert M. Tanguay,Lawrence E. Hightower
Based upon a workshop entitled “The Small HSP international” held in Québec 2-5 October 2014. Twenty-five scientists supplied chapters for the e-book. The chapters are from the easiest scientists at present operating during this field. those colleagues contain Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. in short, the publication starts off with the constitution of small warmth surprise proteins, relocating to their features and completing with their involvement in ailments. even supposing this can be really wide, the structural element would be the unifying topic of the book.