Mitochondria and Cell Death (Cell Death in Biology and by David M. Hockenbery

By David M. Hockenbery

This quantity examines the position of mitochondria in several kinds of telephone loss of life, together with apoptotic and necrotic telephone deaths. themes mentioned contain mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; middle techniques equivalent to calcium dealing with, fission and fusion, reactive oxygen species iteration, and upkeep of mitochondrial DNA constancy and protein folding homeostasis; and retrograde signaling among mitochondria and different mobile elements, together with the real function of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary overseas views, lending a nuanced and complete method of the material.
Mitochondria and phone Death, a part of the Cell dying in Biology and Diseases sequence, is beneficial analyzing for graduate scholars, researchers, and clinicians within the fields of neuroscience, oncology, gastroenterology, and hepatology, in addition to these attracted to the examine of mitochondria and mobile biology.

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Regenerative Medicine Technology: On-a-Chip Applications for by Sean V. Murphy,Anthony Atala

By Sean V. Murphy,Anthony Atala

Miniaturization within the fields of chemistry and molecular biology has led to the "lab-on-a-chip." Such structures are micro-fabricated units able to dealing with tremendous small fluid volumes facilitating the scaling of unmarried or a number of lab strategies all the way down to a microchip-sized layout. The convergence of lab-on-a-chip know-how with the sphere of phone biology facilitated the improvement of "organ-on-a-chip" structures. Such structures simulate the functionality of tissues and organs, having the aptitude to avoid a few cellphone and animal checking out tools. those applied sciences have generated excessive curiosity as purposes for disorder modeling and drug discovery.

This booklet, edited by means of Drs. Sean Murphy and Anthony Atala, presents a complete insurance of the applied sciences which have been used to boost organ-on-a-chip platforms. recognized leaders conceal the fundamentals to the main proper and novel issues within the box, together with micro-fabrication, 3D bio-printing, 3D phone tradition strategies, biosensor layout and microelectronics, micro-fluidics, facts assortment, and predictive research. The e-book describes particular tissue varieties amenable for ailment modeling and drug discovery purposes. Lung, liver, center, pores and skin and kidney "on-a-chip" applied sciences are incorporated in addition to a growth file on designing a complete "body-on-a-chip" procedure. also, the ebook covers functions of varied structures for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and offers an outline of present and strength purposes of those platforms to disorder modeling, toxicity trying out, and individualized medicine.

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Biotechnology and Production of Anti-Cancer Compounds by Sonia Malik

By Sonia Malik

This booklet discusses cancers and the resurgence of public curiosity in plant-based and natural medications. It additionally describes methods of acquiring anti-cancer medicinal drugs from crops and bettering their creation utilizing biotechnological recommendations. It offers tools equivalent to cellphone tradition, shoot and root tradition, bushy root tradition, purification of plant uncooked fabrics, genetic engineering, optimization of tradition stipulations in addition to metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. furthermore, it describes the purposes and boundaries of large-scale creation of anti-cancer compounds utilizing biotechnological capability. finally, it discusses destiny reasonably-priced and green concepts for acquiring anti-cancer compounds utilizing biotechnology. 

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The EGF Receptor Family: Biologic Mechanisms and Role in by Graham Carpenter

By Graham Carpenter

The enormity of the literature on development components, plus the breadth of the organic disciplines and technical services required prohibits a finished overview by means of even a multi-disciplinary panel of authors. to supply another that's possible for authors and digestible via readers, this overview compendium involves a suite of articles, every one masking a facet of teh ErbB/EGF box. This compilation gains articles on development issue ligands, neuregulins, and person receptors. the second one a part of the ebook concentrates at the organic context of the ErbB receptors, relatively in mammary improvement and in melanoma. It concludes with a dialogue of the genetic structures that experience enabled major advances in examine during this area.

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Cell Death Signaling in Cancer Biology and Treatment: 1 by Daniel Johnson

By Daniel Johnson

A key target within the therapy of melanoma is to accomplish selective and effective killing of tumor cells. the purpose of Cell loss of life Signaling in melanoma Biology and Treatment is to explain state of the art ways and destiny possibilities for reaching this aim by way of concentrating on mechanisms and pathways that control melanoma mobile loss of life. during this e-book, molecular defects in cellphone demise signaling that represent melanoma cells, together with dysregulation of telephone loss of life because of overexpression/hyperactivation of oncoproteins, in addition to the lack of tumor suppressor proteins could be defined. the potential of focusing on microRNAs should be mentioned. a number of chapters will describe preclinical and scientific methods which are at the moment getting used to focus on epigenetic alterations, DNA fix pathways, and protein chaperones, as a way of upsetting tumor phone demise. ultimately, the advance and alertness of novel brokers and methods for concentrating on particular parts of phone loss of life signaling pathways and equipment may be reviewed.

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Plant Tissue Culture: Propagation, Conservation and Crop by Mohammad Anis,Naseem Ahmad

By Mohammad Anis,Naseem Ahmad

This ebook provides easy techniques, methodologies and functions of biotechnology for the conservation and propagation of fragrant, medicinal and different monetary vegetation. It caters to the desires and demanding situations of researchers in plant biology, biotechnology, the clinical sciences, pharmaceutical biotechnology and pharmacology components by way of supplying an obtainable and cost effective sensible method of micro-propagation and conservation suggestions for plant species. it is also illustrations describing an entire documentation of the implications and learn into specific plant species performed by way of the authors during the last five years.

Plant Biotechnology has been an issue of educational curiosity for a substantial time. in recent times, it has additionally turn into a great tool in agriculture and medication, in addition to a well-liked quarter of organic learn. present financial progress is globally projected in a hugely optimistic demeanour, however the demanding situations many nations face in regards to foodstuff, feed, malnutrition, infectious ailments, the newly pointed out life style ailments, and effort shortages, all of that are worsened via an ever-deteriorating surroundings, proceed to drag the expansion digits again. the typical thread that connects all the above demanding situations is biotechnology, that could supply many answers.

Molecular biology and biotechnology have now develop into an essential component of tissue tradition learn. The super influence generated by means of genetic engineering and for this reason of transgenics now permits us to govern plant genomes at will. There has certainly been a fast improvement during this quarter with significant successes in either constructed and constructing countries. 

The ebook introduces numerous new and intriguing components to researchers who're strange with plant biotechnology and likewise serves as a overview of ongoing examine and destiny instructions for students. The ebook highlights a variety of tools for in vitro propagation and usage of recommendations in elevating transgenics to assist readers reproduce the experiments discussed.

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Protein Expression: A Practical Approach (Practical Approach by S. J. Higgins,B. D. Hames

By S. J. Higgins,B. D. Hames

a part of a mini-series at the synthesis and processing of proteins, this quantity info the expression of cloned DNA and RNA templates in the entire significant in vivo and in vitro structures. The in vivo structures coated are cultured mammalian cells, the yeasts Sacchoromyces cerevisiae and Pichia pastoris, baculovirus, Xenopus oocytes, and prokaryotic cells. It additionally covers cell-free structures of either eukaryotes and prokaryotes, together with prokaryotic structures that provide coupled transcription-translation. the quantity concludes with a bankruptcy on tracking protein expression.

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Regenerative Medicine: Using Non-Fetal Sources of Stem Cells by Niranjan Bhattacharya,Phillip George Stubblefield

By Niranjan Bhattacharya,Phillip George Stubblefield

This ebook represents an incredible contribution to the emerging science of regenerative drugs utilizing non-fetal resources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have introduced jointly probably the most pre-eminent scientists engaged on regenerative drugs to proportion details on presently ongoing paintings during this sector along unpublished observations that might support to form the contours of destiny therapies.

Regenerative drugs: utilizing Non-Fetal resources of Stem Cells discusses the aptitude scientific and healing functions utilizing non-fetal stem cells in addition to supplying guide at the assortment, isolation and characterization of stem cells from numerous non-fetal resources, resembling menstrual blood, adipose tissue, breast milk and uprooted decidual teeth.

This booklet could be a useful source for either energetic researches and people getting into the sphere. The Editors actually desire that the textual content will act as a stimulant to pros and medical scientists, who might be encouraged to extra the paintings of the pioneering scientists who've contributed to this volume.

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Trends in Biophysics: From Cell Dynamics Toward by Pavel Kraikivski

By Pavel Kraikivski

This name contains a variety of Open entry chapters.

This booklet covers a large scope of organic ways to such organic phenomena as mobilephone department, motility, collective phone habit, multicellular buildings, morphogenesis, and tumor improvement. over the last 20 years, biologists have generated huge units of experimental info and chanced on loads of evidence that desire clarification. This organic growth draws physicists who think they could support to enhance a theoretical framework in biology and clarify whole organic phenomena utilizing uncomplicated principles.

This is the 1st e-book to give contemporary advances in biophysical experiences of the several points of mobilephone lifestyles. This ebook offers contemporary advances in biophysical experiences of residing cells and provides the effect mixture of quantitative stay mobilephone observations, designated biochemical and biophysical info, and mathematical modeling are able to reply to many vital organic questions and to accomplish a extra whole knowing of such advanced phenomena.

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International Review of Cell and Molecular Biology: 290 by Kwang W. Jeon

By Kwang W. Jeon

International evaluation of Cell and Molecular Biology presents present advances and finished reports in phone biology--both plant and animal. Articles deal with constitution and keep an eye on of gene expression, nucleocytoplasmic interactions, keep watch over of phone improvement and differentiation, and phone transformation and progress. effect issue for 2009: 6.088.

  • Authored by means of a few of the preferable scientists within the field
  • Provides up to date info and instructions for destiny research
  • Valuable reference fabric for complicated undergraduates, graduate scholars scientists

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